{"id":19621,"date":"2020-05-07T18:56:53","date_gmt":"2020-05-07T16:56:53","guid":{"rendered":"https:\/\/devhml.givememore.net\/?page_id=19621"},"modified":"2022-02-10T15:02:13","modified_gmt":"2022-02-10T14:02:13","slug":"recherche-covid","status":"publish","type":"page","link":"https:\/\/devhml.givememore.net\/hopital\/epidemie-covid\/recherche-covid\/","title":{"rendered":"Recherche Covid"},"content":{"rendered":"\n

Les programmes de recherche<\/h2>\n\n\n\n

Etudes promotion GHPSJ<\/h3>\n\n\n\n

Cohorte COVID GHPSJ-cit\u00e9 H<\/strong> – PI : B. Pilmis<\/strong><\/span> – RIPH\/HJ : HJ
Titre<\/span> : Devenir des patients infect\u00e9s ou suspects d\u2019\u00eatre infect\u00e9s par le Covid-19 et pris en charge par le GHPSJ et les \u00e9tablissements de la cit\u00e9 hospitali\u00e8re Paris Plaisance.<\/p>\n\n\n\n

Cohorte COVID HML<\/strong> – PI : S. Hasco\u00ebt<\/span><\/strong><\/span> – RIPH\/HJ : HJ
Titre<\/span> : Devenir des patients infect\u00e9s Covid-19 et prise en charge en lien avec l\u2019H\u00f4pital Marie Lannelongue<\/p>\n\n\n\n

DHYSCO<\/strong> – PI : F. St\u00e9phan<\/span><\/strong> – RIPH\/HJ : RIPH 1
Titre<\/span> : Effet de la Dexamethasone combin\u00e9e \u00e0 l\u2019hydroxychloroquine dans le traitement pr\u00e9coce des SDRA s\u00e9v\u00e8re li\u00e9 \u00e0 l\u2019infection par SARS-Cov2<\/p>\n\n\n\n

OUTCOV<\/strong> – PI : JM Naccache<\/strong><\/span> – RIPH\/HJ : RIPH 1
Titre<\/span> : Etude randomis\u00e9e, adaptative, de l’efficacit\u00e9 et de la s\u00e9curit\u00e9 des traitements pr\u00e9coces en ambulatoire de l’infection COVID-19 chez des patients ayant des facteur de risque de gravit\u00e9. Une strat\u00e9gie de pr\u00e9vention de l’hospitalisation<\/p>\n\n\n\n

COSTA<\/strong> – PI : F. Philippart<\/strong><\/span> – RIPH\/HJ : HJ
Titre<\/span> : Pathog\u00e8nes impliqu\u00e9s dans les infections secondaires au cours des formes s\u00e9v\u00e8res de pneumonie \u00e0 Covid-19<\/p>\n\n\n\n

BIOCOVID<\/strong> – PI : F. Philippart<\/strong><\/span> – RIPH\/HJ : RIPH 3
Titre<\/span> : Place des biomarqueurs circulants et des eicosanoides respiratoires dans le pronostic des formes s\u00e9v\u00e8res de pneumonie \u00e0 Covid-19 : BioCovid study<\/p>\n\n\n\n

CLOVID<\/strong> – PI : F. Philippart<\/span><\/strong> – RIPH\/HJ : RIPH 3
Titre<\/span> : Place de la Clonidine dans le pronostic des formes s\u00e9v\u00e8res de pneumonie \u00e0 Covid-19 : Etude Clovid<\/p>\n\n\n\n

LPSARS2<\/strong> – PI : F. Philippart<\/span><\/strong> – RIPH\/HJ : RIPH 3
Titre<\/span> : Etude de la possibilit\u00e9 de pr\u00e9diction de la d\u00e9gradation respiratoire, par biomarqueurs au cours des formes s\u00e9v\u00e8res de pneumonie \u00e0 Covid-19<\/p>\n\n\n\n

COVAP<\/strong> – PI : F. Philippart<\/strong><\/span> – RIPH\/HJ : RIPH 3
Titre<\/span> : Pathog\u00e8nes impliqu\u00e9s dans les infections secondaires au cours des formes s\u00e9v\u00e8res de pneumonie \u00e0 Covid-19<\/p>\n\n\n\n

SEROCOVID GHPSJ<\/strong> – PI : A. Gigandon<\/strong><\/span> – RIPH\/HJ : RIPH 2
Titre<\/span> : \u00c9tude de la r\u00e9ponse immunitaire des patients infectes par le sars-cov-2 en fonction de la gravite clinique des patients<\/p>\n\n\n\n

PREDISCAN<\/strong> – PI : O. Mercier<\/strong><\/span> – RIPH\/HJ : RIPH 1 – HPS
Titre<\/span> : Pr\u00e9diction de l\u2019\u00e9volution vers la fibrose chronique des l\u00e9sions pulmonaires li\u00e9es \u00e0 l\u2019infection SARSCoV2 \u00e0 partir d\u2019images scannographiques.<\/p>\n\n\n\n

COVENTRY<\/strong> – PI : G. Choukroun – A. Leneindre<\/span><\/strong> – RIPH\/HJ : RIPH 2
Titre<\/span> : Qualit\u00e9 de vie et pronostic fonctionnel \u00e0 1 an des patients atteints du COVID 19 apr\u00e8s un s\u00e9jour en r\u00e9animation. Une \u00e9tude de cohorte.<\/p>\n\n\n\n

PsyCOVIDUM post partum<\/strong> – PI : E. Azria<\/span> <\/strong>– RIPH\/HJ : RIPH 2
Titre<\/span> : Estimation de la pr\u00e9valence des manifestations anxieuses et d\u00e9pressives dans le post-partum en contexte de pand\u00e9mie COVID-19<\/p>\n\n\n\n

COVID-Risque Pro Anesth<\/strong> – PI : P. Alfonsi<\/strong> <\/span>– RIPH\/HJ : RIPH 2
Titre<\/span> : COVID-Risque Pro Anesth: Identification \u00e0 l\u2019aide d\u2019un questionnaire des patients asymptomatiques infect\u00e9s au Covid-19 dans la population devant avoir une anesth\u00e9sie<\/p>\n\n\n\n

SPACE<\/strong> – PI : J. Worsmer<\/strong> <\/span>– RIPH\/HJ : HJ
Titre<\/span> : Spontaneaous breathing and Prone position for Acute respiratory failure during Covid Epidemic: SPACE<\/p>\n\n\n\n

COVID PALADIN<\/strong> – PI : J. Emmerich<\/strong><\/span> – RIPH\/HJ : HJ
Titre<\/span> : Registre national des \u00e9v\u00e8nements thrombotiques art\u00e9riels li\u00e9s \u00e0 l\u2019infection par COVID-1<\/p>\n\n\n\n

COVID-GREFFE<\/strong> – PI : S. Mussot<\/strong><\/span> – RIPH\/HJ : HJ
Titre<\/span> : Devenir des patients transplant\u00e9s d\u2019un organe solide infect\u00e9s ou suspects d\u2019\u00eatre infect\u00e9s par le Covid-19 et pris en charge par une structure hospitali\u00e8re en France<\/p>\n\n\n\n

OBVIONCO<\/strong> – PI : E. Raymond<\/strong><\/span> – RIPH\/HJ : RIPH 2
Titre<\/span> : Etude prospective permettant de d\u00e9crire les caract\u00e9ristiques cliniques du COVID-19, la r\u00e9ponse immunitaire acquise et les param\u00e8tres biologiques et cliniques des patients suivis en Oncologie par le groupe hospitalier Saint-Joseph \u00e0 Paris en France pendant une p\u00e9riode de 6 mois durant la pand\u00e9mie du COVID-19 en 2020<\/p>\n\n\n\n

CIN-Covid-19 \/ STP-Covid-1<\/strong> – PI : A. Lemonnier<\/strong> <\/span>– RIPH\/HJ : RIPH2
Titre<\/span> : Evaluation des concentrations d\u2019hydroxychloroquine (HCQ) et d\u2019azithromycine (AZT) dans le sang total et le s\u00e9rum des patients COVID-19 hospitalis\u00e9s au GHPSJ<\/p>\n\n\n\n

Etudes promotion externe<\/h3>\n\n\n\n

COVID-ICU<\/strong> – Promoteur : REVA & Covid – PI : Dr Cedric BRUEL<\/span><\/strong>
M\u00e9dicament test\u00e9<\/span> : NA
Titre<\/span> : Infection \u00e0 COVID-19 en r\u00e9animation. \u00c9tude COVID-ICU<\/p>\n\n\n\n

20-15 \/ DisCoVeRy<\/strong> – Promoteur : INSERM – PI : Dr Cedric BRUEL – Dr J\u00e9r\u00f4me Le Pavec<\/span><\/strong>
M\u00e9dicament test\u00e9<\/span> : Remdesivir – Lopinavir \/ Ritonavir – Lopinavir \/ Ritonavir plus interf\u00e9ron (IFN) -\u00df-1 – hydroxychloroquine
Titre<\/span> : Etude multicentrique, randomis\u00e9e, adaptative, de l\u2019efficacit\u00e9 et de la s\u00e9curit\u00e9 des traitements des patients adultes hospitalis\u00e9s pour une infection COVID-19<\/p>\n\n\n\n

CORONADO<\/strong> – Promoteur : Soci\u00e9t\u00e9 fran\u00e7aise diab\u00e9tique – PI : Dr Olivier Dupuy<\/strong><\/span>
M\u00e9dicament test\u00e9<\/span> : NA
Titre<\/span> : \u00abCoronavirus SARS-CoV2 and Diabetes Outcomes\u00bb<\/p>\n\n\n\n

HOME-CoV<\/strong> – Promoteur : CHU d’Angers – PI : Dr Elo\u00efse TRABATTONI<\/span><\/strong>
M\u00e9dicament test\u00e9<\/span> : NA
Titre<\/span> : Hospitalisation ou prise en charge ambulatoire des patients ayant une infection \u00e0 SARSCoV-2 av\u00e9r\u00e9e ou probable<\/p>\n\n\n\n

COVID par TAKEDA<\/strong> – Promoteur : Takeda – PI : Dr C\u00e9dric Bruel<\/span><\/strong>
M\u00e9dicament test\u00e9<\/span> : Polyclonal anti-COVID-19 – Hyperimmune Globulin
Titre<\/span> : An open label trial design on high-risk patients hospitalized with COVID-19 and a design in Healthcare Professionals at High Risk of Exposure to SARS-CoV-2 virus<\/p>\n\n\n\n

MICROVID<\/strong> – Promoteur : CHU de bordeaux – PI : Dr Fran\u00e7ois Philippart<\/span><\/strong>
M\u00e9dicament test\u00e9<\/span> : NA
Titre<\/span> : Lung microbiota in mechanically-ventilated ARDS COVID-19 patients: Microvid study<\/p>\n\n\n\n

NEURO COVID<\/strong> – Promoteur : L’Association ICTAL GROUP – PI : Dr C\u00e9dric Bruel<\/strong><\/span>
M\u00e9dicament test\u00e9<\/span> : NA
Titre<\/span> : \u00ab Enc\u00e9phalopathie aigu\u00eb chez les patients de soins critiques avec infection \u00e0 SARS-COV-2 (\u00e9tude NEURO-COVID-19) \u00bb<\/p>\n\n\n\n

IMMUNONCOVID-20<\/strong> – Promoteur : Centre L\u00e9on B\u00e9rard – PI : Dr Albane de Kerautem<\/span><\/strong>
M\u00e9dicament test\u00e9<\/span> : chloroquine analog (GNS561) – nivolumab – tocilizumab
Titre<\/span> : Etude prospective, contr\u00f4l\u00e9e, randomis\u00e9e, multicentrique comparant l\u2019efficacit\u00e9 d\u2019un analogue de la chloroquine (GNS561), d\u2019une immunoth\u00e9rapie par anti-PD1 (nivolumab) et d\u2019un anti-interleukine-6R (tocilizumab) par rapport \u00e0 la prise en charge standard chez des patients atteints de cancer avanc\u00e9 ou m\u00e9tastatique et pr\u00e9sentant une infection au SARS-CoV-2 (COVID-19)<\/p>\n\n\n\n

COVIDICUS<\/strong> – Promoteur : APHP – PI : Dr C\u00e9dric Bruel<\/span><\/strong>
M\u00e9dicament test\u00e9<\/span> : Dexamethasone
Titre<\/span> : Dexamethasone and oxygen support strategies in ICU patients with Covid-19 pneumoniA<\/p>\n\n\n\n

ANACONDA<\/strong> – Promoteur : CHU Tours – PI : Dr Joseph Emmerich<\/span><\/strong>
M\u00e9dicament test\u00e9<\/span> : Anakinra
Titre<\/span> : Efficacit\u00e9 et tol\u00e9rance de l\u2019Anakinra chez des adultes pr\u00e9sentant une maladie \u00e0 Coronavirus 2019 avec aggravation des sympt\u00f4mes respiratoires : essai contr\u00f4l\u00e9 randomis\u00e9 multicentrique en ouvert. ANACONDA-COVID-19<\/p>\n\n\n\n

COVID Phase 2 NOVARTIS<\/strong> – Promoteur : NOVARTIS – PI : Dr C\u00e9dric Bruel<\/strong><\/span>
M\u00e9dicament test\u00e9<\/span> : DFV890, un inhibiteur NLRP3
Titre<\/span> : A phase 2, randomized, controlled, open-label multi-center study, to assess the safety and efficacy of DFV890 in patients with COVID-19 pneumonia and impaired respiratory function\u201d<\/p>\n\n\n\n

Etude 214094 GSK<\/strong> – Promoteur : GSK – PI : Dr C\u00e9dric Bruel<\/strong><\/span>
M\u00e9dicament test\u00e9<\/span> : Otilimab
Titre<\/span> : L\u2019Otilimab (anti-GM-CSF) : essai de phase 3<\/p>\n\n\n\n

COVIPREG<\/strong> – Promoteur : APHP – PI : Pr Elie Azria<\/strong><\/span>
M\u00e9dicament test\u00e9<\/span> : NA
Titre<\/span> : \u00ab prevalence et consequences de l\u2019infection sars-cov-2 chez la femme enceinte, le foetus et le nouveau-ne\u00bb covipreg<\/p>\n\n\n\n

Cohorte nationale GCO-002 CACOVID-19<\/strong> – Promoteur : FFCD – PI : Pr Eric Raymond<\/strong><\/span>
M\u00e9dicament test\u00e9<\/span> : NA
Titre<\/span> : Cohorte non interventionnelle ambispective nationale multicentrique de patients suivis pour cancer et infect\u00e9s par le SARS-CoV-2<\/p>\n\n\n\n

RUX-COVID<\/strong> – Promoteur : NOVARTIS – PI : Dr St\u00e9phane Jouveshomme<\/span><\/strong>
M\u00e9dicament test\u00e9<\/span> : Ruxolitinib
Titre<\/span> : Phase 3 randomised, double-blind, placebo-controlled multi-center study to assess the efficacy and safety of ruxolitinib in patients with COVID-19 (RUXCOVID)<\/p>\n\n\n\n

COVISEP<\/strong> – Promoteur : APHP – PI : Pr Mathieu Zuber<\/span><\/strong>
M\u00e9dicament test\u00e9<\/span> : NA
Titre<\/span> : \u00c9tude de cohorte \u00e9valuant les caract\u00e9ristiques \u00e9pid\u00e9miologiques de l\u2019infection \u00e0 Coronavirus chez les patients atteints de SEP ou de NMO<\/p>\n\n\n\n

INHASCO<\/strong> – Promoteur : APHP – PI : Dr Pauline Pradere<\/span><\/strong>
M\u00e9dicament test\u00e9<\/span> : Symbicort rapihaler 200 ug
Titre<\/span> : Etude ouverte randomis\u00e9e testant l’efficacit\u00e9 du Symbicort rapihaler 200 ug 2 bouff\u00e9es matin et soir administr\u00e9s par une chambre d’inhalation<\/p>\n\n\n\n

LILIADE-COVID<\/strong> – Promoteur : APHP – PI : Dr C\u00e9dric Bruel<\/span><\/strong>
M\u00e9dicament test\u00e9<\/span> : Low dose of IL-2
Titre<\/span> : Low dose of IL-2 In Acute respiratory DistrEss syndrome related to COVID-19<\/p>\n\n\n\n

COVID ACHA<\/strong> – Promoteur : \u00ab Adult Congenital Heart Association \u00bb – PI : Dr S\u00e9bastien Hasco\u00ebt<\/span><\/strong>
M\u00e9dicament test\u00e9<\/span> : NA
Titre<\/span> : VID-19 in Adults with Congenital Heart Disease<\/p>\n\n\n\n

ECMO-SARS<\/strong> – Promoteur : CHU de Rennes – PI : Pr Olaf Mercier<\/span><\/strong>
M\u00e9dicament test\u00e9<\/span> : NA
Titre<\/span> : Place de l\u2019ECMO dans la prise en charge des d\u00e9faillances respiratoires et\/ou myocardiques associ\u00e9es au SARS-CoV 2: \u00e9tude de cohorte multicentrique nationale<\/p>\n\n\n\n

ACICOVID-19<\/strong> – Promoteur : CHU Toulon – PI : Dr C\u00e9dric Bruel<\/span><\/strong>
M\u00e9dicament test\u00e9<\/span> : NA
Titre<\/span> : Registre r\u00e9trospectif et prospectif ACICOVID-19, \u00e9tude d\u2019incidence et d\u2019\u00e9valuation des facteurs de risque de survenue d\u2019un arr\u00eat cardiaque chez les patients atteints d\u2019une infection \u00e0 Covid-19.<\/p>\n\n\n\n

CARDIO-COVID<\/strong> – Promoteur : ICU Californie, Palo Alto – PI : Dr Julien Guihaire<\/span><\/strong>
M\u00e9dicament test\u00e9<\/span> : NA
Titre<\/span> : Caract\u00e9ristiques cliniques des patients COVID-19 pr\u00e9sentant une atteinte myocardique admis en soins intensifs et en r\u00e9animation (Registre CARDIO-COVID)<\/p>\n\n\n\n

Essai IgIV<\/strong> – Promoteur : GHU Paris – PI : Dr C\u00e9dric Bruel<\/span><\/strong>
M\u00e9dicament test\u00e9<\/span> : Immunoglobulines intraveineuses
Titre<\/span> : Int\u00e9r\u00eat d\u2019un traitement pr\u00e9coce par immunoglobulines polyvalentes enrichies en immunoglobuline M dans le prise en charge du syndrome de d\u00e9tresse respiratoire associ\u00e9 aux infections par SARS-CoV-2.<\/p>\n","protected":false},"excerpt":{"rendered":"

Les programmes de recherche Etudes promotion GHPSJ Cohorte COVID GHPSJ-cit\u00e9 H – PI : B. Pilmis – RIPH\/HJ : HJTitre : Devenir des patients infect\u00e9s ou suspects d\u2019\u00eatre infect\u00e9s par le Covid-19 et pris en charge par le GHPSJ et les \u00e9tablissements de la cit\u00e9 hospitali\u00e8re Paris Plaisance. Cohorte COVID HML – PI : S. […]<\/p>\n","protected":false},"author":9,"featured_media":0,"parent":19615,"menu_order":4,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"advgb_blocks_editor_width":"","advgb_blocks_columns_visual_guide":"","site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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